Methyl Isocyanate → 8-(2,6-Difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-[1-(2-aminoethyl)-3-methylureido]-8H-pyrido[2,3-d]pyrimidin-7-one

Participants

Role	Name	HCID	Charge
Reactant	Methyl Isocyanate	HCID 12228	—
Reactant	2-[(2-Aminoethyl)amino]-8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)pyrido[2,3-d]pyrimidin-7(8H)-one	HCID 59639577	—
Product	8-(2,6-Difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-[1-(2-aminoethyl)-3-methylureido]-8H-pyrido[2,3-d]pyrimidin-7-one	HCID 66893902	59.5%

Reaction Steps

The title compound from Example 157 (150 mg, 0.00035 mol) was treated with methylisocyanate (22 uL, 21.6 mg, 0.00035 mol) in the same manner as described in Example 158. Purification afforded 100.5 mg (59%) of the title compound as a light red solid (m.p. 124°-133°) LC MS (m/e) 452 (MH+). Rt=1.85 min.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07314934B2
Source dataset	uspto-grants-2008_01
ORD ID	ord-851594633f47439a85d3163c4d3991c9
Source note	uspto-grants-2008_01