HCID 59640494, compound → HCID 59640425, compound

HRID 2250140Notes

Reaction equation

HRID 2250140 reaction equation
C(OC(=O)[NH:10][C:11]1([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][CH2:23][N:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)=[CH:16][CH:15]=2)[CH2:13][CH2:12]1)C1C=CC=CC=1>C(O)C.[Pd]>[N:24]1([CH2:23][CH2:22][CH2:21][O:20][C:17]2[CH:16]=[CH:15][C:14]([C:11]3([NH2:10])[CH2:12][CH2:13]3)=[CH:19][CH:18]=2)[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1

Participants

4

Reactant 1

HCID 59640494HCID 59640494, compound

Product 1

HCID 59640425HCID 59640425, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

{1-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-cyclopropyl}-carbamic acid benzyl ester (1.08 g, 2.65 mmol) is dissolved in ethanol (50 mL), and 10% Pd/C is added (200 mg). The mixture was stirred under a balloon on hydrogen for 3 hours. The reaction mixture was stirred through a plug of silica gel to give the desired compound. HRMS 275.2123 (M+H)+.

Workup

  1. stirringThe reaction mixture was stirred through a plug of silica gel

Sources & evidence

ORD record
ord-59a363fdde464ddca3c0c95936774d25
Source dataset
uspto-grants-2008_01
Patent number
US07314937B2

Reaction notes

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