反应详情

To a stirred solution of 2-benzyloxycarbonylamino-3-(6-benzyloxy-pyridin-3-yl)-propionic acid methyl ester (130 mg, 0.31 mmol) in methylene chloride (5 mL, 0° C.) was added trimethylsilyl iodide (44 μL, 1.0 equiv). The ice bath was removed and stirring continued for 1 h. Reaction was poured into saturated sodium bicarbonate, extracted with ethyl acetate (3×), washed with brine, dried over magnesium sulfate, and concentrated to give 81 mg (91%) which was used without purification. Mass spec.: 287.37 (MH)+.

1. customThe ice bath was removed
2. customReaction
3. extractionextracted with ethyl acetate (3×)
4. washwashed with brine
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated
7. customto give 81 mg (91%) which
8. customwas used without purification