3-(Methylsulphonyl)-2-oxoimidazolidine-1-carbonyl chloride → HCID 53644563, compound

HRID 225024Notes

Reaction equation

HRID 225024 reaction equation
O.O.[NH2:3][CH:4]([C:8]1[N:9]=[C:10]([NH:13][C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[S:11][CH:12]=1)[C:5]([OH:7])=[O:6].Cl[C:25]([N:27]1[CH2:31][CH2:30][N:29]([S:32]([CH3:35])(=[O:34])=[O:33])[C:28]1=[O:36])=[O:26]>C1COCC1.O>[O:36]=[C:28]1[N:29]([S:32]([CH3:35])(=[O:34])=[O:33])[CH2:30][CH2:31][N:27]1[C:25]([NH:3][CH:4]([C:8]1[N:9]=[C:10]([NH:13][C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[S:11][CH:12]=1)[C:5]([OH:7])=[O:6])=[O:26]

Participants

4

Reactant 2

HCID 30162993-(Methylsulphonyl)-2-oxoimidazolidine-1-carbonyl chlorideHCID 86737352HCID 86737352, compound

Product 1

HCID 53644563HCID 53644563, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

The compound is prepared analogously to Example 6 (a) from 15 g of α-amino-α-(2-benzyloxycarbonylamino-thiazol-4-yl)-acetic acid dihydrate in THF/water (1:1) and 10.9 g 1-chlorocarbonyl-2-oxo-3-methylsulfonyl-imidazolidine in a pH-range from 7.5 to 8.0. 14.1 g (65% of theory) are obtained.

Workup

  1. custom14.1 g (65% of theory) are obtained

Sources & evidence

ORD record
ord-0907125cb33443f5a9cd4061126fd020
Source dataset
uspto-grants-1980_11
Patent number
US04235774

Reaction notes

Loading…