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温度

0 °C

A stirred solution of (2-amino-6-methoxy-benzyl)-(1-benzyl-piperidin-4-yl)-amine (0.2 g, 0.62 mmol) in tetrahydrofuran (3 mL) at 0° C. was treated with carbonyl diimidazole (99 mg, 0.62 mmol). The reaction was stirred for 30 min at 0° C. and at reflux for 1 h. After cooling to room temperature, the solvent was evaporated and the residue purified by column to afford 150 mg (68%) of the desired product. LC/MS: tR=1.41 min, 352.30 (MH)+.

1. temperatureat reflux for 1 h
2. temperatureAfter cooling to room temperature
3. customthe solvent was evaporated
4. customthe residue purified by column