1,1'-Carbonyldiimidazole → HCID 58772590, compound

HRID 2250353Notes

Reaction equation

HRID 2250353 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8][NH2:9])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1.[C:17](N1C=CN=C1)(N1C=CN=C1)=[O:18].ClC1C=CC=CC=1C1C(C2C=CC(Cl)=CC=2)=CC2N(C(=O)NN=2)N=1>>[Cl:1][C:2]1[C:3]([C:10]2[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=2)=[CH:4][C:5]2[N:6]([C:17](=[O:18])[NH:9][N:8]=2)[N:7]=1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 58772592HCID 58772592, compoundHCID 596416776-(2-chlorophenyl)-7-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one

Product 1

HCID 58772590HCID 58772590, compoundYield 80%

Procedure

The title compound (900 mg, 80%) as a yellow solid was prepared from 1-(6-chloro-5-(4-chlorophenyl)pyridazin-3-yl)hydrazine (1.02 g, 4.0 mmol) and 1,1′-carbonyl diimidazole (3.24 g, 20.0 mmol) according to the procedures described for 6-(2-chlorophenyl)-7-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (Example 1G). LC/MS (method A): retention time=2.77 min, (M+H)+=281.

Sources & evidence

ORD record
ord-804c0bff670d440da7ac3746d92ec2cf
Source dataset
uspto-grants-2008_01
Patent number
US07317012B2

Reaction notes

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