Methyl Acrylate → HCID 18440999, compound

HRID 2250416Notes

Reaction equation

HRID 2250416 reaction equation
[C:1]1([CH:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[O:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:21]([O:25][CH3:26])(=[O:24])[CH:22]=[CH2:23]>CO>[C:15]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:23][CH2:22][C:21]([O:25][CH3:26])=[O:24])[CH2:11][CH2:10]2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 30175844-Benzhydryloxypiperidine

Product 1

HCID 18440999HCID 18440999, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-(diphenylmethoxy)piperidine (5) (1.4 g, 5.2 mmol), methyl acrylate (560 mg, 6.5 mmol) and methanol (9.5 mL) was placed on a preheated orbital shaker at 75° C. for 3 h. The yellow solution was concentrated to yield 1.8 g (98%) of 6b as a yellow oil. The structure was confirmed by 1H NMR. (The propanoate esters 6c and 6e were similarly prepared.)

Workup

  1. concentrationThe yellow solution was concentrated

Sources & evidence

ORD record
ord-ab722879ed4445f79fb449db24f4a931
Source dataset
uspto-grants-2008_01
Patent number
US07317026B2

Reaction notes

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