Methyl 6-aminonicotinate → Methyl 6-amino-5-iodopyridine-3-carboxylate

To 5 g 6-Amino-nicotinic acid methyl ester and 16.2 g Bis(pyridine)iodonium(I) tetrafluoroborate in 250 mL DCM, 7.6 mL Trifluoromethanesulfonic acid were added dropwise at 0° C. The mixture was stirred for 24 h at RT. Then additional 3.2 g Bis(pyridine)iodoniun(I) tetrafluoroborate and 1.5 mL Trifluoromethanesulfonic acid were added. After stirring for 2 h at RT the reaction mixture was concentrated under reduced pressure and then taken-up with concentrated aqueous Na2SO3 solution and brought to pH 8 with concentrated aqueous ammonia. The mixture was extracted with ethyl acetate (2×150 ml). The combined organic layers were washed with brine and then dried over MgSO4. After filtration the solvent was removed under reduced pressure and the residue was codestilled with 100 mL toluene. Yield: 9.6 g.

1. stirringAfter stirring for 2 h at RT the reaction mixture
2. concentrationwas concentrated under reduced pressure
3. extractionThe mixture was extracted with ethyl acetate (2×150 ml)
4. washThe combined organic layers were washed with brine
5. dry with materialdried over MgSO4
6. filtrationAfter filtration the solvent
7. customwas removed under reduced pressure

ORD record

ord-ffb9600f885f44b7a1ecfee2898574a2

Source dataset

uspto-grants-2008_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07317027B2