反应详情

3-Amino-5-(3-ethoxypropyl)-5H-dibenzo[a,d]cyclohepten-5-ol (10 g., 0.032 mole) and sodium borohydride (12.3 g., 0.325 mole) are ground together in a mortar. The mixture is added in portions to 250 ml. of trifluoroacetic acid, cooled in ice, and stirred vigorously under a stream of nitrogen in an efficient fume hood. Upon completion of the addition, the mixture is stirred for 15 minutes and the bulk of the trifluoroacetic acid removed under vacuum.

1. additionThe mixture is added in portions to 250 ml
2. additionUpon completion of the addition
3. stirringthe mixture is stirred for 15 minutes
4. customthe bulk of the trifluoroacetic acid removed under vacuum