1,2-Diamino-4,5-difluorobenzene → HCID 22139821, compound

HRID 2250512Notes

Reaction equation

HRID 2250512 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[NH2:10].[Cl:11][C:12]1[C:13]([N:17]=[C:18]=[S:19])=[CH:14][S:15][CH:16]=1>C1COCC1>[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[NH:10][C:18]([NH:17][C:13]1[C:12]([Cl:11])=[CH:16][S:15][CH:14]=1)=[S:19]

Participants

4

Reactant 2

HCID 27367551,2-Diamino-4,5-difluorobenzeneHCID 22139828HCID 22139828, compound

Product 1

HCID 22139821HCID 22139821, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To 1,2-diamino-4,5-difluorobenzene (1.02 g) in THF abs. (15 ml) 4-chloro-3-thienylisothiocyanate (1.25 g, example 52c) dissolved in THF abs. (15 ml) was added. Following the analogous description in example 54a) the desired product was obtained (773 mg).

Workup

  1. addition(15 ml) was added

Sources & evidence

ORD record
ord-df9440969dd64cd5a52e126580c73179
Source dataset
uspto-grants-2008_01
Patent number
US07317033B2

Reaction notes

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