反应详情

To a solution of 1.24 g of the ester from Step 1 in 14 mL of tetrahydrofuran (THF) at room temperature, 7 mL of MeOH followed by 7 mL of 2N NaOH were added. After 2.5 h, the reaction mixture was poured into a separatory funnel containing ethyl acetaqte (EtOAc)/1N HCl. The phases were separated and the acidic phase was extracted twice with EtOAc. The organic layers were combined, washed with brine, dried over anhydrous Na2SO4 and evaporated to dryness to yield 1.08 g of a crude and unstable waxy brown oil that was used as such in the next step (>90% purity).

1. customat room temperature
2. additionwere added
3. additionthe reaction mixture was poured into a separatory funnel
4. additioncontaining ethyl acetaqte (EtOAc)/1N HCl
5. customThe phases were separated
6. extractionthe acidic phase was extracted twice with EtOAc
7. washwashed with brine
8. dry with materialdried over anhydrous Na2SO4
9. customevaporated to dryness
10. customto yield 1.08 g of a crude and unstable waxy brown oil that