HCID 69311657, compound → HCID 69311658, compound

HRID 2250622Notes

Reaction equation

HRID 2250622 reaction equation
C([O:5][C:6](=[O:37])[CH2:7][O:8][CH2:9][C:10]1[C:11]([CH2:28][CH2:29][CH2:30][CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])=[C:12]([C:21]2[CH:22]=[N:23][CH:24]=[C:25]([CH3:27])[CH:26]=2)[C:13]2[N:14]([C:16]([CH2:19][CH3:20])=[CH:17][CH:18]=2)[N:15]=1)(C)(C)C>FC(F)(F)C(O)=O>[CH2:35]([O:34][C:32](=[O:33])[CH2:31][CH2:30][CH2:29][CH2:28][C:11]1[C:10]([CH2:9][O:8][CH2:7][C:6]([OH:37])=[O:5])=[N:15][N:14]2[C:16]([CH2:19][CH3:20])=[CH:17][CH:18]=[C:13]2[C:12]=1[C:21]1[CH:22]=[N:23][CH:24]=[C:25]([CH3:27])[CH:26]=1)[CH3:36]

Participants

3

Reactant 1

HCID 69311657HCID 69311657, compound

Product 1

HCID 69311658HCID 69311658, compoundYield 103%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of ethyl 5-[2-[(2-tert-butoxy-2-oxoethoxy)methyl]-7-ethyl-4-(5-methyl-3-pyridinyl)pyrrolo[1,2-b]pyridazin-3-yl]pentanoate (60 mg) in trifluoroacetic acid (2 mL) was stirred at ambient temperature for 2 hours, and evaporated in vacuo to give {[3-(5-ethoxy-5-oxopentyl)-7-ethyl-4-(5-methyl-3-pyridinyl)pyrrolo[1,2-b]pyridazin-2-yl]methoxy}acetic acid as brown oil (55 mg).

Workup

  1. customevaporated in vacuo

Sources & evidence

ORD record
ord-14c9cd110f1d4cb4a5fbee9d22c83d05
Source dataset
uspto-grants-2008_01
Patent number
US07317009B2

Reaction notes

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