HCID 68802434, compound → HCID 69309153, compound

HRID 2250651Notes

Reaction equation

HRID 2250651 reaction equation
[CH2:1]([C:3]1[N:7]2[N:8]=[C:9]([CH3:27])[C:10]([CH2:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[C:11]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([CH:18]=[CH2:19])[CH:13]=3)[C:6]2=[CH:5][CH:4]=1)[CH3:2]>CO.[Pd]>[CH2:1]([C:3]1[N:7]2[N:8]=[C:9]([CH3:27])[C:10]([CH2:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[C:11]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][CH3:19])[CH:13]=3)[C:6]2=[CH:5][CH:4]=1)[CH3:2]

Participants

4

Reactant 1

HCID 68802434HCID 68802434, compound

Product 1

HCID 69309153HCID 69309153, compoundYield 92.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 5-[7-ethyl-2-methyl-4-(2-vinyl-4-pyridinyl)pyrrolo[1,2-b]pyridazin-3-yl]pentanoic acid (15 mg) in MeOH was added 10% Pd/C (2 mg). The mixture was stirred under hydrogen atomosphere (1 atm) for 6 h. The reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo. The residue was triturated with hexane to give 5-[7-ethyl-4-(2-ethyl-4-pyridinyl)-2-methylpyrrolo[1,2-b]pyridazin-3-yl]pentanoic acid (14 mg) as an yellow solid.

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe residue was triturated with hexane

Sources & evidence

ORD record
ord-c1730118b14d4c6e8e897ddcef566eec
Source dataset
uspto-grants-2008_01
Patent number
US07317009B2

Reaction notes

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