Diisopropylethylamine → HCID 86584921, compound

HRID 2250709Notes

Reaction equation

HRID 2250709 reaction equation
Cl[CH2:2][C:3]1[CH:28]=[CH:27][C:6]([C:7]([NH:9][C:10]2[S:11][C:12]3[C:18]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)=[CH:17][CH:16]=[C:15]([O:25][CH3:26])[C:13]=3[N:14]=2)=[O:8])=[CH:5][CH:4]=1.[CH3:29][NH:30][CH2:31][CH2:32][O:33][C:34](=[O:45])[C:35]1[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[C:37]([O:43][CH3:44])[CH:36]=1.C(N(C(C)C)C(C)C)C>>[CH3:26][O:25][C:15]1[C:13]2[N:14]=[C:10]([NH:9][C:7]([C:6]3[CH:5]=[CH:4][C:3]([CH2:2][N:30]([CH3:29])[CH2:31][CH2:32][O:33][C:34](=[O:45])[C:35]4[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[C:37]([O:43][CH3:44])[CH:36]=4)=[CH:28][CH:27]=3)=[O:8])[S:11][C:12]=2[C:18]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 22283106HCID 22283106, compoundHCID 68495085HCID 68495085, compound

Product 1

HCID 86584921HCID 86584921, compoundYield 57%

Procedure

Conversion of 4-cloromethyl-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide (84 mg, 0.20 mmol) with 3,4-dimethoxybenzoic acid 2-methylamino-ethyl ester chlorohydrate (96 mg, 0.4 mmol) and N-ethyl diisopropylamine (0.14 ml, 0.80 mmol) using the general procedure C affords the product as light yellow solid in 57% yield. MS: m/e=621 (M+H+).

Sources & evidence

ORD record
ord-0af6c9f8842f4891aa2569b86fb0bb00
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

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