反应详情

温度

100 °C

To a suspension of 2-amino-4-methoxy-7-phenyl-benzothiazole (1.52 g, 6 mmol) in dioxane (60 ml) was added benzoylisothiocyanate (1.45 g, 8.9 mmol) and the mixture heated to 100° C. for 2 h, during which time the suspension dissolved. After cooling the solvent was removed and the solids suspended in hot acetonitrile (100 ml) and filtered while warm (50° C.). The solid collected was washed with acetonitrile (20 ml) then dried under vacuum (0.05 mmHg), at 60° C. to afford the title compound as a pale yellow amorphous solid (1.38 g, 55% yield), MS: m/e=419.0 (M+).

1. dissolutiondissolved
2. temperatureAfter cooling the solvent
3. customwas removed
4. filtrationfiltered
5. temperaturewhile warm (50° C.)
6. customThe solid collected
7. washwas washed with acetonitrile (20 ml)
8. customthen dried under vacuum (0.05 mmHg), at 60° C.