Pyridine → HCID 86584943, compound

HRID 2250746Notes

Reaction equation

HRID 2250746 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:13]([C:15]3[S:16][C:17]([CH3:20])=[CH:18][CH:19]=3)=[O:14])[S:11][C:7]=2[C:6]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:5][CH:4]=1.[C:27](Cl)(=[O:29])[CH3:28].N1C=CC=CC=1>CN(C=O)C>[C:27]([N:24]1[CH2:23][CH2:22][N:21]([C:6]2[C:7]3[S:11][C:10]([NH:12][C:13]([C:15]4[S:16][C:17]([CH3:20])=[CH:18][CH:19]=4)=[O:14])=[N:9][C:8]=3[C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH2:26][CH2:25]1)(=[O:29])[CH3:28]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 865849425-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-piperazin-1-yl-benzothiazol-2-yl)-amide

Product 1

HCID 86584943HCID 86584943, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-piperazin-1-yl-benzothiazol-2-yl)-amide (100 mg, 0.26 mmol) were suspended in DMF (2 ml) and treated with acetyl chloride (22 μl, 0.30 mmol) and pyridine (27 μl, 0.34 mmol) and the mixture stirred for 5 h at ambient temperature. Workup and purification as described in the general procedure C afforded the product as a white solid (55%), MS: m/e=431(M+H+).

Workup

  1. customWorkup and purification

Sources & evidence

ORD record
ord-cc70ee9be0994124a06dd9c89ca4fded
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

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