5-Methylthiophene-2-carbonyl chloride → 5-Methyl-thiophene-2-carboxylic acid [7-(3-dimethylamino-pyrrolidin-1-yl)-4-methoxy-benzothiazol-2-yl]-amide

HRID 2250752Notes

Reaction equation

HRID 2250752 reaction equation
[CH3:1][C:2]1[S:6][C:5]([C:7](Cl)=[O:8])=[CH:4][CH:3]=1.[CH3:10][N:11]([CH3:29])[CH:12]1[CH2:16][CH2:15][N:14]([C:17]2[C:25]3[S:24][C:23]([NH2:26])=[N:22][C:21]=3[C:20]([O:27][CH3:28])=[CH:19][CH:18]=2)[CH2:13]1>>[CH3:10][N:11]([CH3:29])[CH:12]1[CH2:16][CH2:15][N:14]([C:17]2[C:25]3[S:24][C:23]([NH:26][C:7]([C:5]4[S:6][C:2]([CH3:1])=[CH:3][CH:4]=4)=[O:8])=[N:22][C:21]=3[C:20]([O:27][CH3:28])=[CH:19][CH:18]=2)[CH2:13]1

Participants

3

Reactant 2

HCID 27600835-Methylthiophene-2-carbonyl chlorideHCID 222830977-(3-Dimethylamino-pyrrolidin-1-yl)-4-methoxy-benzothiazol-2-yl-amine

Product 1

HCID 865849145-Methyl-thiophene-2-carboxylic acid [7-(3-dimethylamino-pyrrolidin-1-yl)-4-methoxy-benzothiazol-2-yl]-amide

Procedure

Using 5-methyl-thiophene-2-carbonyl chloride and 7-(3-dimethylamino-pyrrolidin-1-yl)-4-methoxy-benzothiazol-2-yl-amine the title compound was prepared using the general method of example 1 as yellow solid (90%), MS: m/e=417 (M+H+).

Sources & evidence

ORD record
ord-de4c3468b3cd4bb78707cdff8bb6c1ae
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

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