Piperidine → 4-Fluoro-N-(4-isopropoxy-7-piperidin-1-yl-benzothiazol-2-yl)-benzamide

HRID 2250761Notes

Reaction equation

HRID 2250761 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH:9]([CH3:11])[CH3:10])=[C:4]([N+:12]([O-])=O)[CH:3]=1.[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1.[F:21][C:22]1[CH:47]=[CH:46][C:25]([C:26]([NH:28][C:29]2[S:30]C3C(N4CCOCC4)=CC=C(OC)C=3N=2)=[O:27])=[CH:24][CH:23]=1>>[F:21][C:22]1[CH:47]=[CH:46][C:25]([C:26]([NH:28][C:29]2[S:30][C:3]3[C:2]([N:15]4[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]4)=[CH:7][CH:6]=[C:5]([O:8][CH:9]([CH3:11])[CH3:10])[C:4]=3[N:12]=2)=[O:27])=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 102002144-fluoro-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamideHCID 222832414-Bromo-1-isopropoxy-2-nitrobenzene

Product 1

HCID 222833834-Fluoro-N-(4-isopropoxy-7-piperidin-1-yl-benzothiazol-2-yl)-benzamide

Procedure

The title compound was prepared strarting from 4-bromo-1-isopropoxy-2-nitro-benzene and piperidine as described for 4-fluoro-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide (Example 275) and obtained as a light brown solid in 10% overall yield, MS: m/e=414 (M+H+).

Workup

  1. customobtained as a light brown solid in 10% overall yield, MS

Sources & evidence

ORD record
ord-3f2a3c8c6e2949ef82b6849bd10172be
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

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