4-Methoxypiperidine → HCID 86584950, compound

HRID 2250764Notes

Reaction equation

HRID 2250764 reaction equation
BrC1C=CC(OC)=C([N+]([O-])=O)C=1.[CH3:13][O:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.[CH3:21][O:22][C:23]1[C:28]2[N:29]=[C:30]([NH:32][C:33]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)=[O:34])[S:31][C:27]=2[C:26](N2CCOCC2)=[CH:25][CH:24]=1>>[CH3:21][O:22][C:23]1[C:28]2[N:29]=[C:30]([NH:32][C:33]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)=[O:34])[S:31][C:27]=2[C:26]([N:18]2[CH2:19][CH2:20][CH:15]([O:14][CH3:13])[CH2:16][CH2:17]2)=[CH:25][CH:24]=1

Participants

4

Reactant 3

HCID 776664-MethoxypiperidineHCID 1185334-Bromo-2-nitroanisoleHCID 86584923HCID 86584923, compound

Product 1

HCID 86584950HCID 86584950, compound

Procedure

The title compound was prepared strarting from 4-bromo-1-methoxy-2-nitro-benzene and 4-methoxy-piperidine as described for morpholine-4-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide (Example 136) and obtained as a light yellow solid in about 10% overall yield, MS: m/e=407 (M+H+).

Workup

  1. customobtained as a light yellow solid in about 10% overall yield, MS

Sources & evidence

ORD record
ord-3133b6c74c3245989a95c634405c613f
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

Loading…