反应详情

To a cold solution of 166 g of 4-hydroxy-1-octyne [Prostaglandins, 10, 289 (1975)], and 240 g of imidazole in one liter of dimethylformamide is added dropwise 202 g of chlorotrimethylsilane. The mixture is allowed to stand at room temperature for 2 to 3 days. The mixture is partitioned with water and hexane. The hexane layer is washed with brine dried over magnesium sulfate, and concentrated. Distillation of the residue gives a colorless liquid, bp 38° C. (0.2 mm).

1. customThe mixture is partitioned with water and hexane
2. washThe hexane layer is washed with brine
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated
5. distillationDistillation of the residue
6. customgives a colorless liquid, bp 38° C. (0.2 mm)