Methyl iodide → Hydrogen iodide

HRID 2250822Notes

Reaction equation

HRID 2250822 reaction equation
[CH:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9](=[S:11])[NH2:10])[CH2:5][CH2:4]1)=[O:2].[CH3:12][I:13]>CO>[IH:13].[CH:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9](=[NH:10])[S:11][CH3:12])[CH2:5][CH2:4]1)=[O:2]

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 186230804-Formylpiperazine-1-carbothioamide

Product 2

HCID 24841Hydrogen iodideHCID 18623083HCID 18623083, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

25.5 g of 4-formyl-1-piperazinecarbothioamide are suspended in 80 ml of methanol, treated with 22 g of methyliodide and refluxed. Within ca. 10 minutes a clear solution is obtained. The mixture is cooled to room temperature. The solvent is evaporated. Crystalline hydroiodide of 4-formyl-1-[imino(methylthio)methyl]piperazine is obtained.

Workup

  1. temperaturerefluxed
  2. customWithin ca. 10 minutes a clear solution is obtained
  3. customThe solvent is evaporated

Sources & evidence

ORD record
ord-4ace7a5532a44715ac2d8c82cf3436b6
Source dataset
uspto-grants-2008_01
Patent number
US07317101B2

Reaction notes

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