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HRID2250835

反应详情

EQUATION

反应方程式

HRID 2250835 的结构方程式

REACTANTS

反应物

1
结构：CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@H]([C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](O)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@@H]2O
HCID65366

Baccatin III

C31H38O11

PRODUCTS

生成物

1
结构：CC(=O)OC1C(=O)[C@@H]2C(O)CC3OC[C@H]3[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)CC(=O)C(C)=C1C2(C)C
HCID101380543

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Mn+4].[O-2].[O-2]
催化剂HCID178418406

未命名化合物

结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Baccatin III (150 g, 0.25 mol) was dissolved in acetone (1.43 I). Commercially available manganese dioxide (450 g) was added in three portions under strong stirring. After the starting product disappeared (4 h) the suspension was filtered and the solvent evaporated off. The crude was suspended in EtOAc (100 ml) and refluxed for 1 h, then c-Hex (100 ml) was added. The title compound was obtained from mother liquors, after evaporation of the solvent, as white solid (140 g, 95%).

WORKUP

后处理

  1. custom(4 h)
  2. filtrationwas filtered
  3. customthe solvent evaporated off
  4. temperaturerefluxed for 1 h
  5. additionc-Hex (100 ml) was added