Baccatin Iii → HCID 101380543, compound

Participants

Reaction Steps

Baccatin III (150 g, 0.25 mol) was dissolved in acetone (1.43 I). Commercially available manganese dioxide (450 g) was added in three portions under strong stirring. After the starting product disappeared (4 h) the suspension was filtered and the solvent evaporated off. The crude was suspended in EtOAc (100 ml) and refluxed for 1 h, then c-Hex (100 ml) was added. The title compound was obtained from mother liquors, after evaporation of the solvent, as white solid (140 g, 95%).

Provenance & Evidence