Potassium Carbonate → HCID 18452789, compound

Temperature

55 °C

Part A: A solution of 1-ethylpropylamine (1.97 g, 22.6 mmol) in acetonitrile (50 mL) was treated with K2CO3 (9.3 g, 67.7 mmol) 2-bromopropionitrile (3.0 g, 22.6 mmol) and KI (4.13 g, 24.9 mmol). The mixture was heated at 55° C. for 20 h. The mixture was cooled to room temperature and was filtered through a pad of Celite. The filtrate was concentrated and the residue was purified by column chromatography on silica gel (2% MeOH in CH2Cl2) to afford 2-(1-ethylpropylamino)-propionitrile (1.04 g, 36% yield) as a yellow oil.

1. temperatureThe mixture was cooled to room temperature
2. filtrationwas filtered through a pad of Celite
3. concentrationThe filtrate was concentrated
4. customthe residue was purified by column chromatography on silica gel (2% MeOH in CH2Cl2)

ORD record

ord-301fa4f325234a14874d49267c736143

Source dataset

uspto-grants-2008_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07319100B2