Phosphorus oxychloride → 9-Chloro-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline

HRID 2251109Notes

Reaction equation

[Cl:1][C:2]1[N:3]2[C:7]([N:8]=[C:9]3[CH2:15][CH2:14][CH2:13][CH2:12]C[C:10]=13)=[CH:6][CH:5]=[N:4]2.P(Cl)(Cl)(Cl)=O>>[Cl:1][C:2]1[N:3]2[N:4]=[CH:5][CH:6]=[C:7]2[N:8]=[C:9]2[C:10]=1[CH2:12][CH2:13][CH2:14][CH2:15]2

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 5858769810-chloro-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene

Product 1

HCID 638208079-Chloro-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline

Procedure

Using the method described for the preparation of 10-chloro-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene, the reaction of 7,8-tetrahydro-pyrazolo[5,1-b]quinazolin-9-ol and phosphorus oxychloride provided the title compound.

Sources & evidence

ORD record: ord-dc097dbc6f6a4ff39884654b925c672f
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07319103B2

Reaction notes

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