HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpyrrolidine → 9-{4-[3-(2-Methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpyrrolidine | HCID 13003 | — |
| Reactant | 10-{4-[3-(2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene | HCID 11611130 | — |
| Reactant | 9-[4-(3-Chloro-propoxy)-phenyl]-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline | HCID 69255787 | — |
| Product | 9-{4-[3-(2-Methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline | HCID 11668259 | — |
Reaction Steps
Using the method described for the preparation of 10-{4-[3-(2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene, the reaction of 9-[4-(3-chloro-propoxy)-phenyl]-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline and 2-methyl-pyrrolidine provided the desired compound 9-{4-[3-(2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319103B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-cdc319d4adc04610873a880d33ded8c4 |
| Source note | uspto-grants-2008_01 |