2-Methylpyrrolidine → 9-{4-[3-(2-Methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline

HRID 2251113Notes

Reaction equation

HRID 2251113 reaction equation
[CH3:1][CH:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[N:18]3[C:22]([N:23]=[C:24]4C[CH2:29][CH2:28][CH2:27][CH2:26][C:25]=24)=[CH:21][CH:20]=[N:19]3)=[CH:13][CH:12]=1.ClCCCOC1C=CC(C2N3N=CC=C3N=C3C=2CCCC3)=CC=1.CC1CCCN1>>[CH3:1][CH:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[CH:13][C:14]([C:17]2[N:18]3[N:19]=[CH:20][CH:21]=[C:22]3[N:23]=[C:24]3[C:25]=2[CH2:26][CH2:27][CH2:28][CH2:29]3)=[CH:15][CH:16]=1

Participants

4

Reactant 3

HCID 130032-MethylpyrrolidineHCID 1161113010-{4-[3-(2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indeneHCID 692557879-[4-(3-Chloro-propoxy)-phenyl]-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline

Product 1

HCID 116682599-{4-[3-(2-Methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline

Procedure

Using the method described for the preparation of 10-{4-[3-(2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene, the reaction of 9-[4-(3-chloro-propoxy)-phenyl]-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline and 2-methyl-pyrrolidine provided the desired compound 9-{4-[3-(2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline.

Sources & evidence

ORD record
ord-cdc319d4adc04610873a880d33ded8c4
Source dataset
uspto-grants-2008_01
Patent number
US07319103B2

Reaction notes

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