1-Bromo-3-chloropropane → 8-[4-(3-Chloro-propoxy)-phenyl]-6,7-dihydro-5H-1,4,8a-triaza-s-indacene
Reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]3[C:17]([N:18]=[C:19]4[CH2:25]CC[CH2:22][CH2:21][C:20]=24)=[CH:16][CH:15]=[N:14]3)=[CH:8][CH:7]=1.N1N2C(N=C3C(=C2C2C=CC(O)=CC=2)CCC3)=CC=1.BrCCCCl>>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]3[C:17](=[CH:16][CH:15]=[N:14]3)[N:18]=[C:19]3[C:20]=2[CH2:21][CH2:22][CH2:25]3)=[CH:8][CH:7]=1Participants
4
Reactant 3
Product 1
Procedure
Using the method described for the preparation of 10-[4-(3-chloro-propoxy)-phenyl]-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene, the reaction of 4-(6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-phenol and 1-bromo-3-chloropropane provided the title compound.
Sources & evidence
- ORD record
- ord-d147f9fb1cd54f7b83871b32674f9560
- Source dataset
- uspto-grants-2008_01
- Patent number
- US07319103B2
Reaction notes
Loading…