4-(Tetrahydro-2H-pyran-2-yloxy)phenylboronic Acid (contains varying amounts of Anhydride) → 8-[4-(Tetrahydro-pyran-2-yloxy)-phenyl]-5H,7H-6-oxa-1,4,8a-triaza-s-indacene

HRID 2251133Notes

Reaction equation

HRID 2251133 reaction equation
C(OC1C=CC(C2N3C(N=C4CCCCCC=24)=CC=N3)=CC=1)C1C=CC=CC=1.Cl[C:30]1[N:41]2[C:37](=[CH:38][CH:39]=[N:40]2)[N:36]=[C:35]2[C:31]=1[CH2:32][O:33][CH2:34]2.[O:42]1[CH2:47][CH2:46][CH2:45][CH2:44][CH:43]1[O:48][C:49]1[CH:54]=[CH:53][C:52](B(O)O)=[CH:51][CH:50]=1>>[O:42]1[CH2:47][CH2:46][CH2:45][CH2:44][CH:43]1[O:48][C:49]1[CH:54]=[CH:53][C:52]([C:30]2[N:41]3[C:37](=[CH:38][CH:39]=[N:40]3)[N:36]=[C:35]3[C:31]=2[CH2:32][O:33][CH2:34]3)=[CH:51][CH:50]=1

Participants

4

Reactant 3

HCID 50176524-(Tetrahydro-2H-pyran-2-yloxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 5858771710-(4-benzyloxy-phenyl)-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indeneHCID 585877188-Chloro-5H,7H-6-oxa-1,4,8a-triaza-s-indacene

Product 1

HCID 585877238-[4-(Tetrahydro-pyran-2-yloxy)-phenyl]-5H,7H-6-oxa-1,4,8a-triaza-s-indacene

Procedure

Using the method described for the preparation of 10-(4-benzyloxy-phenyl)-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene, the reaction of 8-Chloro-5H,7H-6-oxa-1,4,8a-triaza-s-indacene and 4-(Tetrahydro-pyran-2-yloxy)-phenyl boronic acid provided the title compound.

Sources & evidence

ORD record
ord-1186467dfa98428fa6dbb2cf88e10fde
Source dataset
uspto-grants-2008_01
Patent number
US07319103B2

Reaction notes

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