p-Toluenesulfonic acid → 4-(5,6,7,8-Tetrahydro-pyrazolo[5,1-b]quinazolin-9-yl)-phenol

HRID 2251134Notes

Reaction equation

HRID 2251134 reaction equation
O1CCCCC1[O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:25]3[C:21](=[CH:22][CH:23]=[N:24]3)[N:20]=[C:19]3[C:15]=2COC3)=[CH:10][CH:9]=1.[C:26]1(C)[CH:31]=CC(S(O)(=O)=O)=[CH:28][CH:27]=1>CO>[N:24]1[N:25]2[C:21]([N:20]=[C:19]3[C:15](=[C:14]2[C:11]2[CH:10]=[CH:9][C:8]([OH:7])=[CH:13][CH:12]=2)[CH2:28][CH2:27][CH2:26][CH2:31]3)=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 585877238-[4-(Tetrahydro-pyran-2-yloxy)-phenyl]-5H,7H-6-oxa-1,4,8a-triaza-s-indacene

Product 1

HCID 1363610224-(5,6,7,8-Tetrahydro-pyrazolo[5,1-b]quinazolin-9-yl)-phenol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8-[4-(Tetrahydro-pyran-2-yloxy)-phenyl]-5H,7H-6-oxa-1,4,8a-triaza-s-indacene (500 mg, 2.5 mmol) was suspended in methanol and added with p-toluenesulfonic acid (50 mg) was catalyst. The mixture was stirred at room temperature for 2 hours and concentrated in vacuo. The residue was carried on to the next reaction without purification.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe residue was carried on to the next reaction without purification

Sources & evidence

ORD record
ord-74a84c58ece743299658d009c6dd69d3
Source dataset
uspto-grants-2008_01
Patent number
US07319103B2

Reaction notes

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