1-Bromo-3-chloropropane → 8-[4-(3-Chloro-propoxy)-phenyl]-5H,7H-6-oxa-1,4,8a-triaza-s-indacene

HRID 2251135Notes

Reaction equation

HRID 2251135 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]3[C:17]([N:18]=[C:19]4[CH2:25]CCC[CH2:21][C:20]=24)=[CH:16][CH:15]=[N:14]3)=[CH:8][CH:7]=1.N1N2C(N=C3C(=C2C2C=CC([OH:45])=CC=2)CCCC3)=CC=1.BrCCCCl>>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]3[C:17](=[CH:16][CH:15]=[N:14]3)[N:18]=[C:19]3[C:20]=2[CH2:21][O:45][CH2:25]3)=[CH:8][CH:7]=1

Participants

4

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 5858770610-[4-(3-chloro-propoxy)-phenyl]-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indeneHCID 1363610224-(5,6,7,8-Tetrahydro-pyrazolo[5,1-b]quinazolin-9-yl)-phenol

Product 1

HCID 585877208-[4-(3-Chloro-propoxy)-phenyl]-5H,7H-6-oxa-1,4,8a-triaza-s-indacene

Procedure

Using the method described for the preparation of 10-[4-(3-Chloro-propoxy)-phenyl]-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene, the reaction of 4-(5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazolin-9-yl)-phenol and 1-bromo-3-chloropropane provided the title compound which was used without further purification.

Sources & evidence

ORD record
ord-9a95455343604869984ba6b948238360
Source dataset
uspto-grants-2008_01
Patent number
US07319103B2

Reaction notes

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