N-(2-Aminoethyl)piperidine → HCID 69277575, compound

HRID 2251149Notes

Reaction equation

HRID 2251149 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][CH:22]=1)[CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:16]([OH:18])=O)[CH:12]=2)[C:7]1=[O:19].[N:23]1([CH2:29][CH2:30][NH2:31])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>>[Cl-:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][CH:22]=1)[CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:16]([NH:31][CH2:30][CH2:29][NH+:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)=[O:18])[CH:12]=2)[C:7]1=[O:19]

Participants

3

Reactant 2

HCID 33944N-(2-Aminoethyl)piperidineHCID 69277800HCID 69277800, compound

Product 1

HCID 69277575HCID 69277575, compound

Procedure

2-(3-chloro-benzyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-carboxylic acid (100 mg, 0.316 mmol) and 2-piperidin-1-yl-ethylamine (113 μL, 0.792 mmol) were reacted with each other. Target compound in the amount of 135 mg (92%) was obtained by following the procedure described in Example 1.

Workup

  1. customTarget compound in the amount of 135 mg (92%) was obtained

Sources & evidence

ORD record
ord-4e9130c219364c1686d4791b7f623b26
Source dataset
uspto-grants-2008_01
Patent number
US07319098B2

Reaction notes

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