反应详情

温度

80 °C

A mixture of 20 mmol 1-bromo-2-fluoro-4-trifluoromethyl-benzene, 24.7 mmol n-Boc-piperazine, 0.1 mmol Tris(dibenzylideneacetone)dipalladium chloroform complex, 28.8 mmol sodium-t-butoxide and 0.4 mmol 2-(dicyclohexylphosphino)biphenyl in 50 ml toluene was heated for 16 h at 80° C. After cooling to RT the mixture was treated with 15 g Isolute HM-N and all volatiles were removed under vacuum. The residue was purified on silica eluting with a gradient of heptane/EtOAc to yield after evaporation the title compound.

1. temperatureAfter cooling to RT the mixture
2. additionwas treated with 15 g Isolute HM-N
3. customall volatiles were removed under vacuum
4. customThe residue was purified on silica eluting with a gradient of heptane/EtOAc
5. customto yield
6. customafter evaporation the title compound