Trifluoroacetic acid → 2,3-Difluoro-4-piperazin-1-yl-benzonitrile trifluoro-acetic acid

HRID 2251174Notes

Reaction equation

HRID 2251174 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]#[N:21])=[C:16]([F:22])[C:15]=2[F:23])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>ClCCl>[F:22][C:16]1[C:15]([F:23])=[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:19]=[CH:18][C:17]=1[C:20]#[N:21].[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 688407454-(4-Cyano-2,3-difluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 688402612,3-Difluoro-4-piperazin-1-yl-benzonitrile trifluoro-acetic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-(4-Cyano-2,3-difluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (0.72 g) in dichloromethane (5 mL) was added trifluoroacetic acid, and the reaction mixture was stirred at room temperature for 30 minutes. After such time the reaction mixture was concentrated in vacuo to yield the title compound (0.63 g). MS (m/e): 224.3 (M+H+, 100%).

Workup

  1. concentrationAfter such time the reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-b1301774f8724b70bf76962bd5b5fd77
Source dataset
uspto-grants-2008_01
Patent number
US07319099B2

Reaction notes

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