Hydrochloric Acid → HCID 68822041, compound

HRID 2251177Notes

Reaction equation

HRID 2251177 reaction equation
C[O:2][C:3](=[O:21])[C:4]1[CH:9]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:7]=[CH:6][C:5]=1[O:14][CH2:15][CH2:16][C:17]([F:20])([F:19])[F:18].[OH-].[Na+].Cl>C(O)C>[CH3:13][S:10]([C:8]1[CH:7]=[CH:6][C:5]([O:14][CH2:15][CH2:16][C:17]([F:18])([F:20])[F:19])=[C:4]([CH:9]=1)[C:3]([OH:21])=[O:2])(=[O:12])=[O:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69036106HCID 69036106, compound

Product 1

HCID 68822041HCID 68822041, compoundYield 83.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 5-methanesulfonyl-2-(3,3,3-trifluoro-propoxy)-benzoic acid methyl ester (620 mg) in ethanol at 60° C. was added 1N NaOH solution (3.8 mL), and the reaction mixture was stirred for 15 minutes. After such time, 3.8 ml of 1N HCl was slowly added to the reaction mixture, and the ethanol was evaporated in vacuo. The precipitate was then washed with water several times to give the title compound (497 mg). MS (m/e): 311.0, M−H+, 100%).

Workup

  1. customthe ethanol was evaporated in vacuo
  2. washThe precipitate was then washed with water several times

Sources & evidence

ORD record
ord-2e8e4e12d0834bd8ab10eab492956da5
Source dataset
uspto-grants-2008_01
Patent number
US07319099B2

Reaction notes

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