反应详情

A suspension of 18 mmol sodium carbonate and 9 mmol 2,6-Difluoro-3-sulfino-benzoic acid in 30 ml of methanol was stirred at room temperature for 30 min, then heated to 60° C. 24 mmol of methyl iodide were added and the reaction mixture heated overnight at 60° C. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic phase was discarded and the aqueous phase acidified by addition of concentrated hydrochloric acid. Extraction with ethyl acetate yielded the title compound as a slightly brownish solid. MS (m/e): 235.1 (M−H, 16%)

1. temperatureheated to 60° C
2. temperaturethe reaction mixture heated overnight at 60° C
3. extractionextracted with ethyl acetate
4. additionthe aqueous phase acidified by addition of concentrated hydrochloric acid
5. extractionExtraction with ethyl acetate