Piperazine → 1-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazine

HRID 2251256노트

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HRID 2251256 반응식
[CH:1]1([S:4]([C:7]2[CH:12]=[CH:11][C:10](F)=[C:9]([F:14])[CH:8]=2)(=[O:6])=[O:5])[CH2:3][CH2:2]1.[NH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>CN(C)C(=O)C>[CH:1]1([S:4]([C:7]2[CH:12]=[CH:11][C:10]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[C:9]([F:14])[CH:8]=2)(=[O:6])=[O:5])[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 690421904-Cyclopropanesulfonyl-1,2-difluoro-benzene

생성물 1

HCID 598536651-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazine

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

반응 조건

온도
80 °C

실험 절차

To 0.2 mmol 4-cyclopropanesulfonyl-1,2-difluoro-benzene in 5 ml N,N-dimethylacetamide was added 0.5 mmol piperazine and the mixture was heated at 80° C. for 90 min. The mixture was then concentrated in vacuo to afford the title compound. MS (m/e): 285.0 (M+H+, 100%)

후처리

  1. concentrationThe mixture was then concentrated in vacuo

출처 및 근거

ORD 기록
ord-8e1515e164f3493eac22125bd351aff7
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07319099B2

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