HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2251256Generated: October 25, 2026
Piperazine → 1-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazine
https://huagongshe.com/reaction/2251256
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 4-Cyclopropanesulfonyl-1,2-difluoro-benzene | HCID 69042190 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 1-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazine | HCID 59853665 | — |
Reaction Steps
To 0.2 mmol 4-cyclopropanesulfonyl-1,2-difluoro-benzene in 5 ml N,N-dimethylacetamide was added 0.5 mmol piperazine and the mixture was heated at 80° C. for 90 min. The mixture was then concentrated in vacuo to afford the title compound. MS (m/e): 285.0 (M+H+, 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07319099B2 |
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| Source dataset | uspto-grants-2008_01 |
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| ORD ID | ord-8e1515e164f3493eac22125bd351aff7 |
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| Source note | uspto-grants-2008_01 |
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