Potassium Carbonate → HCID 69037053, compound
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([SH:9])[CH:5]=[CH:6][C:7]=1[F:8].I[CH2:11][CH2:12][C:13]([F:16])([F:15])[F:14].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:8][C:7]1[CH:6]=[CH:5][C:4]([S:9][CH2:11][CH2:12][C:13]([F:16])([F:15])[F:14])=[CH:3][C:2]=1[F:1]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 140 °C
Procedure
To 3.4 mmol 3,4-difluoro-thiophenol and 5.1 mmol 1-iodo-3,3,3-trifluoropropane in 5 ml acetone was added 3.7 mmol potassium carbonate, and the mixture heated at 140° C. for 3 h under microwave irradiation. The reaction mixture was then poured onto water and extracted three times with ethyl acetate. The combined organic phases were then washed with saturated aq. NaCl solution, dried over Na2SO4, and concentrated in vacuo to afford the title compound. MS (m/e): 243.1 (M+H+, 100%)
Workup
- additionThe reaction mixture was then poured onto water
- extractionextracted three times with ethyl acetate
- washThe combined organic phases were then washed with saturated aq. NaCl solution
- dry with materialdried over Na2SO4
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-76c6e3db6d97409e9fd77f65520236e4
- Source dataset
- uspto-grants-2008_01
- Patent number
- US07319099B2
Reaction notes
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