Formic Acid → HCID 12883999, compound

HRID 225126Notes

Reaction equation

HRID 225126 reaction equation
[CH2:1]([O:3][C:4]([CH:6]1[CH2:10][N:9]([C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][C:7]1=O)=[O:5])[CH3:2].[NH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(O)=O>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[CH2:10][N:9]([C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][C:7]=1[NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 6115AnilineHCID 12883998HCID 12883998, compound

Product 1

HCID 12883999HCID 12883999, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 100 g of 1-benzoyl-3-oxopyrrolidin-4-carboxylic acid ethyl ester, 42 ml of aniline and 23 ml of formic acid in 1.2 liters of ethanol is heated to reflux for 15 hours, concentrated by evaporation and the residue is crystallised from the ether/methylene chloride. 3-Anilino-1-benzoyl-2,5-dihydro-1H-pyrrol-4-carboxylic acid ethyl ester is obtained. M.P. 149°-151°.

Workup

  1. temperatureis heated
  2. temperatureto reflux for 15 hours
  3. concentrationconcentrated by evaporation
  4. customthe residue is crystallised from the ether/methylene chloride

Sources & evidence

ORD record
ord-ffd63da07fe543049483ca0e239ff43a
Source dataset
uspto-grants-1980_11
Patent number
US04235907

Reaction notes

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