反应详情

温度

90 °C

To 4.2 mmol 1-cyclopropanesulfonyl-2,3,4-trifluoro-benzene in 20 ml N,N-dimethylacetamide was added 8.9 mmol tert-butyl-1-piperazine carboxylate, and the mixture was heated at 90° C. for 1 h. The mixture was then cooled to room temperature and concentrated in vacuo. The residue was chromatographed on silica gel (eluant: dichloromethane/ethyl acetate gradient) to afford the title compound. MS (m/e): 403.3 (M+H+, 100%)

1. temperatureThe mixture was then cooled to room temperature
2. concentrationconcentrated in vacuo
3. customThe residue was chromatographed on silica gel (eluant: dichloromethane/ethyl acetate gradient)