Hydrochloric Acid → Rac-2-methyl-1-(4-trifluoromethyl-phenyl)-piperazine hydrochloride

HRID 2251269Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH:10]([CH3:24])[CH2:9]1)=O)(C)(C)C.[ClH:25]>O1CCOCC1.CCOCC>[ClH:25].[CH3:24][CH:10]1[CH2:9][NH:8][CH2:13][CH2:12][N:11]1[C:14]1[CH:15]=[CH:16][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:18][CH:19]=1

Participants

Conditions

Temperature: 90 °C

Procedure

To 0.58 mmol rac-3-methyl-4-(4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester in 3 ml dioxane was added 8.7 mmol HCl (as a 4 M solution in dioxane), and the mixture was heated at 90° C. for 3 h. The mixture was then cooled 0° C. and diluted with 10 ml ether. The ensuing white crystals were collected by filtration, washing with ether, and dried in vacuo to afford the title compound.

Workup

temperatureThe mixture was then cooled 0° C.
filtrationThe ensuing white crystals were collected by filtration
washwashing with ether
customdried in vacuo

Sources & evidence

ORD record: ord-fc45f4f6f33c4591b53efdb904c81946
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07319099B2

Reaction notes

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