HCID 12883999, compound → HCID 12884003, compound

HRID 225127Notes

Reaction equation

HRID 225127 reaction equation
C([O:3][C:4]([C:6]1[CH2:10][N:9]([C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][C:7]=1[NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=O)C>C1(OC2C=CC=CC=2)C=CC=CC=1>[C:11]([N:9]1[CH2:10][C:6]2[C:4](=[O:3])[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[NH:19][C:7]=2[CH2:8]1)(=[O:18])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 1

HCID 12883999HCID 12883999, compound

Product 1

HCID 12884003HCID 12884003, compound

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

50 g of 3-anilino-1-benzoyl-2,5-dihydro-1H-pyrrol-4-carboxylic acid ethyl ester are heated at reflux in 500 ml of diphenyl ether for 1.5 hours, the resulting ethanol being continuously distilled off. Upon cooling, the resulting precipitate is filtered by suction, washed with ether and dried. 2-Benzoyl-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b]-quinolin-9-one is obtained. M.P. 275°.

Workup

  1. distillationthe resulting ethanol being continuously distilled off
  2. temperatureUpon cooling
  3. filtrationthe resulting precipitate is filtered by suction
  4. washwashed with ether
  5. customdried

Sources & evidence

ORD record
ord-ffa66ebd891b4297ba6ffbbf7d65caa3
Source dataset
uspto-grants-1980_11
Patent number
US04235907

Reaction notes

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