反应详情

温度

50 °C

A mixture of (3R)-(+)-(tert-butoxycarbonylaminopyrrolidine (1.0 g), p-fluorobenzonitrile (650 mg), cesium carbonate (1.75 g) and 5 ml of DMF was stirred at 50° C. for 12 h. Ethyl acetate and water were then added to the reaction solution, and the organic phase was washed twice with water, dried over sodium sulfate and filtered, and the solvent was removed in vacuo. The residue was purified by preparative HPLC. The product with the molecular weight of 287.36 (C16H21N3O2) was obtained in this way; MS (ESI): 288.20 (M+H+).

1. washthe organic phase was washed twice with water
2. dry with materialdried over sodium sulfate
3. filtrationfiltered
4. customthe solvent was removed in vacuo
5. customThe residue was purified by preparative HPLC
6. customThe product with the molecular weight of 287.36 (C16H21N3O2) was obtained in this way