反应详情

Dissolve 2-carbomethoxy-2-(t-butyl)thiomethyl-indan (557 mg, 2.0 mmol) in methanol (15 mL) and add 1N lithium hydroxide (3.5 mL). Warm briefly to effect solution then stir at room temperature under an argon atmosphere for 1 hour. Reflux for 6 hours, concentrate in vacuo to a volume of 3 mL and dilute to a volume of 15 mL with water. Wash with methylene chloride and acidify and aqueous phase with excess 2N hydrochloric acid. After 5 minutes, collect the resulting white precipitate by filtration and dry to give 2-carboxy-2-(t-butyl)thiomethyl-indan (506 mg, 96%); mp 158°-163° C.

1. temperatureWarm briefly
2. temperatureReflux for 6 hours
3. concentrationconcentrate in vacuo to a volume of 3 mL
4. additiondilute to a volume of 15 mL with water
5. washWash with methylene chloride
6. waitAfter 5 minutes
7. customcollect the resulting white precipitate
8. filtrationby filtration
9. customdry