Water → HCID 23329184, compound

HRID 225142Notes

Reaction equation

HRID 225142 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]2[C:4]([C:8]#N)([CH2:5]2)[CH2:3]1.[OH-:10].[K+].[OH2:12]>>[CH3:1][N:2]1[CH2:7][CH:6]2[C:4]([C:8]([OH:12])=[O:10])([CH2:5]2)[CH2:3]1

Participants

4

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 12199686HCID 12199686, compound

Product 1

HCID 23329184HCID 23329184, compound

Procedure

A solution of 10 g of 3-methyl-3-azabicyclo[3.1.0]-hexane-1-carbonitrile is 60 ml of saturated ethanolic KOH and 20 ml of water is boiled under reflux for 15 hours. After neutralization with hydrochloric acid the mixture is evaporated and the title compound is extracted from the resultant dried residue with hot absolute ethanol (M.P. 193°-195°).

Workup

  1. temperatureunder reflux for 15 hours
  2. customAfter neutralization with hydrochloric acid the mixture is evaporated
  3. extractionthe title compound is extracted from the resultant dried residue with hot absolute ethanol (M.P. 193°-195°)

Sources & evidence

ORD record
ord-1f7c16e7d879450b9f9cf03cf27fb9d0
Source dataset
uspto-grants-1980_11
Patent number
US04235921

Reaction notes

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