HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Bromomethyl)-4-(trifluoromethoxy)benzene → HCID 59643224, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Bromomethyl)-4-(trifluoromethoxy)benzene | HCID 142785 | — |
| Reactant | HCID 69099493 | HCID 69099493 | — |
| Product | HCID 59643224 | HCID 59643224 | — |
Reaction Steps
In a two-step sequence similar to the previous example, alkylation of the above intermediate ethyl 2-(4-{2-[(5-ethylpyrimidin-2-yl)amino]ethyl}phenoxy)propanoate with 4-trifluoromethoxy-benzylbromide (1 eq) (1.5 eq NaH; 80C) followed by hydrolysis of the intermediate ester afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319104B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-0b3ec2efaf184d4bb45c3801f9e93dc5 |
| Source note | uspto-grants-2008_01 |