HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 5-ethyl-N-[2-(4-methoxy-3-methylphenyl)ethyl]pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Chloro-5-ethylpyrimidine | HCID 3572763 | — |
| Reactant | 2-(4-Methoxy-3-methylphenyl)ethan-1-amine | HCID 6484660 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 5-ethyl-N-[2-(4-methoxy-3-methylphenyl)ethyl]pyrimidin-2-amine | HCID 59643398 | 51.4% |
Reaction Steps
Condensation of 2-(4-methoxy-3-methylphenyl)ethanamine (516 mg; 3.12 mmol) with 2-chloro-5-ethyl pyrimidine (446 mg; 3.12 mmol) as per general procedure E (1.5 eq DIEA, nBuOH, 130C, 20 hr) provided 5-ethyl-N-[2-(4-methoxy-3-methylphenyl)ethyl]pyrimidin-2-amine (435 mg; 51% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319104B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-8fa741acc87b443f904d240abf0702fe |
| Source note | uspto-grants-2008_01 |