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HRID2251493

反应详情

EQUATION

反应方程式

HRID 2251493 的结构方程式

REACTANTS

反应物

3
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CCc1cnc(Cl)nc1
HCID3572763

2-Chloro-5-ethylpyrimidine

C6H7ClN2

结构：COc1ccc(CCN)cc1C
HCID6484660

2-(4-Methoxy-3-methylphenyl)ethylamine

C10H15NO

PRODUCTS

生成物

1
结构：CCc1cnc(NCCc2ccc(OC)c(C)c2)nc1
HCID59643398

未命名化合物

收率 51.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCCCO
溶剂HCID263

1-Butanol

C4H10O

PROCEDURE

实验过程

Condensation of 2-(4-methoxy-3-methylphenyl)ethanamine (516 mg; 3.12 mmol) with 2-chloro-5-ethyl pyrimidine (446 mg; 3.12 mmol) as per general procedure E (1.5 eq DIEA, nBuOH, 130C, 20 hr) provided 5-ethyl-N-[2-(4-methoxy-3-methylphenyl)ethyl]pyrimidin-2-amine (435 mg; 51% yield).