Trifluoroacetic acid → HCID 59643274, compound

HRID 2251522Notes

Reaction equation

HRID 2251522 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=2)[CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([CH2:18][CH2:19][CH3:20])[CH:12]=2)=[N:6][CH:7]=1.C([O:36][C:37](=[O:40])[CH2:38]Br)(C)(C)C.C(O)(C(F)(F)F)=O>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:21][C:22]2[CH:23]=[CH:24][C:25]([C:28]([F:29])([F:31])[F:30])=[CH:26][CH:27]=2)[CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:38][C:37]([OH:40])=[O:36])=[C:13]([CH2:18][CH2:19][CH3:20])[CH:12]=2)=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 79177tert-Butyl bromoacetateHCID 59643169HCID 59643169, compound

Product 1

HCID 59643274HCID 59643274, compound

Procedure

Alkylation of 4-(2-{(5-methylpyridin-2-yl)[4-(trifluoromethyl)benzyl]amino}ethyl)-2-propylphenol with tert-butyl-bromo-acetate, followed by standard TFA hydrolysis (as described in previous examples) provided after chromatography the title compound as a white foam.

Sources & evidence

ORD record
ord-f55e4b5fa4eb4e44b85828186a00c9f9
Source dataset
uspto-grants-2008_01
Patent number
US07319104B2

Reaction notes

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